Pathogen Biology

The Pathogen Biology Research Cluster at CTID^R focuses on understanding the biology, evolution, and transmission dynamics of pathogens responsible for vector-borne and other tropical infectious diseases. The cluster investigates the diversity and biology of malaria parasites such as Plasmodium falciparum, Plasmodium vivax infecting both Anopheles and humans, and related species, with particular emphasis on the emergence and spread of resistance to antimalarial drugs such as artemisinin and partner therapies. Research also examines pathogens transmitted by Aedes mosquitoes, including Dengue, Yellow Fever, and Chikungunya, as well as neglected tropical diseases caused by organisms such as Onchocerciasis, Lymphatic filariasis, and Leishmaniasis. In addition, the cluster studies tick-borne diseases affecting livestock and humans, including Rickettsiosis (Spotted Fevers), Babesiosis and Anaplasmosis, etc. The cluster also investigates infections and co-infections in human populations and animals, their implications for disease severity, disease management, treatment efficacy, and transmission.

Using advanced approaches in genomics, transcriptomics, and functional genomics, our researchers aim to uncover the molecular mechanisms underlying pathogen evolution, host–pathogen interactions, and drug resistance, ultimately informing improved diagnostics, treatments, and disease control strategies.